// llm applications

Source: Nate’s Substack

Microsoft, Bayer, and Discovery are running large language models directly on premise—processing confidential contracts, patient records, and proprietary datasets without sending them to third-party servers. This solves a concrete adoption barrier that legal and compliance teams have used to block AI deployment. On-premise inference collapses the false choice between AI capability and data sovereignty. Enterprises can no longer claim they "can't use AI" instead of "won't manage the governance." The competition is now between vendors who can run inference locally and those locked into cloud APIs. This shift changes both enterprise software economics and the physical location of AI computation.